Interferon-stimulated gene

This interaction leads to the expression of a subset of genes involved in the innate immune system response.

[3] Interferon stimulated genes can act as an initial response to pathogen invasion, slowing down viral replication and increasing expression of immune signaling complexes.

[3] Type I interferon consists of INF-α, INF-β, INF-ω and is expressed in response to viral infection.

[6] ISGs induced by type I interferon are associated with viral replication suppression and increase expression of immune signaling proteins.

[7] Type II interferon consists only of INF-γ and is associated with controlling intracellular pathogens and tumor suppressor genes.

[2] The IFIT family of ISGs is located on chromosome 10 in humans and is homologous in mammals, birds, and fish.

[3][5] IFIT gene expression has been observed in response to both DNA and RNA viral infection.

[5] ISGs have a wide range of functions used to combat infection at all stages of a pathogen's lifestyle.

[10] As such a large portion of the human genome is associated with interferon ISG have a broad range of functions.

Cell wide mRNA degradation prevents both viral and host proteins from being produced.