Interior with Portraits is an 1865 genre scene painted by American artist Thomas Le Clear (1818–1882), commissioned by Franklin Sidway (1834–1920).

The painting features two children, James and Parnell Sidway, posing for a photograph in an artist's studio.

The children are surrounded by painted portraits, and the photographer's back is to the viewer with his face obscured.

The girl appears to be supporting the boy and holding him still, as might have been necessary when posing a child for an early photograph due to the long exposure time.

[3] The painting is currently owned by the Smithsonian American Art Museum and the purchase was made possible by a bequest of Pauline Edwards in 1993.