Other major cities connected by I-10 include (from west to east) Los Angeles, Phoenix, Las Cruces, El Paso, San Antonio, Houston, Baton Rouge, New Orleans, Gulfport, Mobile, Pensacola, and Tallahassee.

Another stretch a short distance east in Indio is proclaimed the Doctor June McCarroll Memorial Freeway, named after the nurse known for popularizing road lane striping.

This designation starts at State Route 101 (SR 101; Loop 101), near 99th Avenue, and continues eastward to the interchange southeast of downtown, which is the terminus of I-17.

From the southern terminus of I-17 to the southernmost junction with SR 202 (Loop 202), the highway is signed as the Maricopa Freeway.

This name holds true as well for I-17 from its southern terminus to the Durango Curve south of Buckeye Road.

The highest elevation along I-10 occurs just east of Tucson, 20 miles (32 km) west of Willcox, at the milemarker 320 exit for the rest stop.

I-10 passes through three southern New Mexico municipalities of regional significance before the junction with I-25: Lordsburg, Deming, and Las Cruces.

US 70 leaves I-10 (prior to the junction with I-25), heading northeast to Alamogordo and passing through the north side of Las Cruces.

The junction with I-25 occurs just south of the New Mexico State University campus, on the southern end of Las Cruces.

From the state line with New Mexico (at Anthony) to State Highway 20 (SH 20) in west El Paso, I-10 is bordered by frontage roads South Desert for lanes along I-10 east (actually headed south) and North Desert for lanes along I-10 west (headed north).

I-10 is the western terminus for I-20, and the two highways intersect in Reeves County, about 41 miles (66 km) southwest of Pecos, at milemarker 186.

It is known as I-10 east from the I-10 curve to the Neches River, which is Beaumont's and Jefferson County's eastern boundary line.

Approximately 36 percent of I-10's entire route is located within Texas; the longest segment of any signed Interstate within one state.

I-12 links Baton Rouge to Slidell and bypasses I-10's southward jog through New Orleans by remaining north of Lake Pontchartrain.

On this route, I-10 serves as the southern terminus for I-55 in LaPlace and crosses over a portion of Lake Pontchartrain on the I-10 Bonnet Carré Spillway Bridge.

A dip near the I-10/I-610 junction to travel under a railroad track is one of the lowest points in New Orleans and is highly susceptible to flooding.

They function as spur routes serving lower density or suburban areas west and east of New Orleans respectively.

The highway then crosses approximately eight miles (13 km) of the upper part of Mobile Bay on the Jubilee Parkway, a bridge that local people call the "Bayway".

On the other side of Mobile Bay, the highway goes through the suburban area of Baldwin County before passing through Malbis, Loxley, and then on to the Perdido River to cross over into Florida.

[7] In Tallahassee, Florida, construction was completed in June 2009 on a project to widen a roughly eight-mile (13 km) stretch of I-10 to six lanes (eight in some places).

[8] In Tucson, Arizona, all exits between Prince Road and 22nd Street reopened after an extensive, three-year improvement project.

In 2008, a proposal to make this new highway a toll road and to expedite its construction to complete it in five years surfaced.