Interstate 126 (I-126) is a spur route of I-26 entirely within the city limits of Columbia in the US state of South Carolina.

The terminus is located near the Dutch Square shopping center and I-26's own interchange with I-20, nicknamed "Malfunction Junction", which includes a weaving ramp from I-126's westbound lanes to I-20.

[3] The eight-lane freeway travels southeast along the Saluda River and passes the Riverbanks Zoo at Greystone Boulevard.

The entire length of the freeway is concurrent with US 76, which continues west on I-26 towards Georgia and east to North Carolina.

[11] The South Carolina Department of Transportation (SCDOT), in cooperation with the Federal Highway Administration (FHWA), is proposing improvements to the Interstate corridor of I-20/I-26/I-126, including the system interchanges at I-20/I-26 and I-26/I-126 in Lexington and Richland counties.

It is considered decommissioned as no current state or federal maps list it nor does any physical signage exist.