SC 215 is a two-lane rural highway that traverses for 95.7 miles (154.0 km) from Columbia to Spartanburg; connecting Jenkinsville, Carlisle, Union, and Roebuck.

It originally traveled from U.S. Route 78 (US 78) in Aiken, northeast through Wagener, Pelion, Edmund, and West Columbia.

Through Columbia, in a concurrency with US 1/US 21/SC 2, it heads northwest through Jenkinsville, Carlisle, ending at US 176/SC 92 in Union.

Between 1974 and 1977, SC 215 south of Eau Claire, in Columbia, was removed.

The old alignment between Aiken to Cayce became SC 302, while in Columbia US 21/US 321 remained.