Pennsylvania Route 283 (PA 283, officially designated as SR 300 because of I-283) continues southeast from near the southern terminus of I-283 to Lancaster as a freeway, functioning as an extension of the Interstate, though they are two separate roads.

I-283 continues north-northwest as a four-lane freeway, running past business parks before entering areas of farms and woods, crossing into Swatara Township.

After that exit, the road continues northwest before turning north and passing an industrial park.

[4] Previously, the Harrisburg East interchange of the Pennsylvania Turnpike connected directly to Eisenhower Boulevard.

[5] The ramp from westbound PA 283 and northbound I-283 is being widened to two lanes, and the loop ramp from westbound PA 283 to southbound I-283 toward the Pennsylvania Turnpike toll plaza will be removed and replaced with a left turn and a traffic signal.