The entire length is concurrent with US 11 and State Route 69 (SR 69), with both continuing as at grade thoroughfares north and south of the shorter Interstate.

[4][5] I-359 then continues in a northerly direction paralleling Greensboro Avenue to its northern terminus just north of 15th Street, where the limited access freeway transitions into an at-grade thoroughfare as it enters downtown Tuscaloosa.

[6] From its crossing of the Alabama Great Southern Railroad (AGS) through the northern terminus, the highway in its entirety is elevated along a continuous bridge span.

[2] In 2024, ALDOT will began work to convert the US 11 (Skyland Boulevard)/SR 69 intersection into a single-point urban interchange (SPUI) in order to improve traffic flow.

The project, which is a joint effort between the Tuscaloosa Road Improvement Commission and ALDOT, is expected to cost $89 million and take about three years to complete.