Since completion, this section has undergone much construction to renew bridges over Clear Creek and Washington Street.

[4][5] The freeway heads southeastward for about one mile (1.6 km), crossing over Washington Street and State Highway 224 (SH 224), but access is not provided to either road.

[8] The freeway heads southeast, comes to a westbound exit and eastbound entrance with York Street, and crosses the South Platte River[9] into a commercial area in Adams County.

[14] The freeway heads eastward into Denver,[15] where it has an exit at SH 35, a short highway which continues northward along Quebec Street for one mile (1.6 km).

[17] As part of this role, CDOT periodically conducts surveys on their highways to measure traffic volume.

[20] The Colorado Department of Highways originally planned to use a single number, I-25E, for the entirety of Denver's eastern loop.

[21] The designation was changed to I-225 following correspondence with the American Association of State Highway Officials and split, with the northern leg becoming I-425 in 1958.

[22] The northern leg was then renumbered to I-270 on February 26, 1959, following a request from the Colorado Department of Highways to reflect that it would terminate at I-80S (now I-76) instead of I-25.

[32][33] Citing its significance as a freight corridor, in 2002, the Denver Regional Council of Governments (DRCOG) recommended widening I-270 from four to six lanes by 2025,[34] and it later identified widening I-270 and rebuilding the I-270/Vasquez Boulevard interchange in its 2040 Fiscally Constrained Regional Transportation Plan.

[39] The High Performance Transportation Enterprise, a business within CDOT, additionally ranked I-270 fourth among its top priority corridors for managed lanes, placing it after three segments of I-25 in the Denver metropolitan area.

[40] CDOT began a National Environmental Policy Act (NEPA) study of I-270 in April 2020, scheduled to finish in late 2021[41][needs update] but noted that budget cuts in response to the COVID-19 pandemic could affect the project.