Exit 1, an interchange with Eastern Valley Road, provides access to the large Colonial Promenade shopping center and McCalla community.

Once interchanging with State Route 150 (SR 150) at exit 10, the highway turns northeastward and widens to 10 lanes.

The highway passes east of Mountain Brook while turning northeast and interchanging with Grants Mill Road at exit 27.

In its last few miles, the highway intersects with Derby Parkway and US 11 in Trussville before completing its 33-mile (53 km) course with an interchange at I-59.

Negotiations between the Alabama Department of Transportation (ALDOT) and the city of Hoover are continuing regarding the prospective building of an additional interchange for I-459 at South Shades Crest Road, a heavily traveled traffic artery to help relieve congestion on SR 150.