The bridge and its approach roadways make up a portion of Segment of Independent Utility 4 (SIU 4) of the I-69 corridor from Michigan to Texas.

It will be built approximately 1.62 miles (2.61 km) upstream of the existing Bi-State Vietnam Gold Star Bridges carrying U.S. Route 41 (US 41), at a point just downstream from where the Green River flows into the Ohio.

The I-69 ORX will be constructed about 1.62 miles (2.61 km) east (upstream) of the existing US 41 Bi-State Vietnam Gold Star Bridges linking Evansville, Indiana, with Henderson, Kentucky.

The northern approach to the bridge will tie into the existing I-69 in Indiana (one part formerly I-164) freeway between Green River Road and Weinbach Avenue along Evansville's southeast side.

The I-69 ORX project has been divided into three sections: On June 22, 2022, Kentucky Governor Andy Beshear, Kentucky Transportation Cabinet Secretary Jim Gray, Henderson Mayor Steve Austin, Henderson County Judge/Executive Brad Schneider and Evansville, Indiana, Mayor Lloyd Winnecke broke ground for Phase one of the ORX project.

[5][6] I-69 ORX Section 2 is a bistate project between Indiana and Kentucky that will complete the I-69 connection from US 60 in Henderson to I-69 in Evansville, which includes the new river crossing.

[8] In August 2023, Indiana and Kentucky officials announced that they had requested $630 million in funding from the federal government to complete the bridge and the road segments leading up to it.

On November 16, 2016, INDOT and KYTC announced the selection of Parsons Corporation of Pasadena, California to complete environmental studies and design of the I-69 Ohio River Bridge.

[20] Parsons recently led the engineering and design work for the Ohio River Bridges Project between Louisville, Kentucky and southern Indiana.

The Kentucky General Assembly approved $37 million in Fiscal Years 2020 through 2022 for design, right-of-way, utility relocation, and initial construction between KY-425 and US-60, which includes reconfiguring the US-41 interchange with the Audubon Parkway.

The approved amount is much less than what was originally proposed due to budget shortfalls stemming from the economic disruption caused by the COVID-19 outbreak in 2020.

[26] On May 14, 2020, the Evansville Metropolitan Planning Organization approved an additional $15 million that will enable INDOT and KYTC to complete environmental studies and begin preliminary design.