A seven-mile (11 km) section was left unconstructed from US 41 Alternate south to I-24 despite its approval in 1976 from the Parkway Authority for construction.

The section between the Wendell H. Ford Western Kentucky Parkway near Mortons Gap and the northern terminus in Henderson became part of I-69 with the passage of federal legislation on June 6, 2008.

In the case of the Pennyrile, toll booths were removed in 1992 when bonds were paid off ten years ahead of schedule.

The US 41 designation has since been removed and applied to the former US 41A through Madisonville and other nearby cities; this road was the original US 41 before the parkway opened.

This redesignation followed a horrendous blizzard on January 17, 1994, which forced the then-Kentucky governor Brereton C. Jones to close all Interstates and limited access highways in the state.

This work was completed on the Pennyrile Parkway segment, exits were renumbered to match I-69's statewide mileage, and I-69 signs finally went up in 2013.