Farther north in Georgia, I-75 continues on through Macon and Atlanta before running through Chattanooga and Knoxville and the Cumberland Mountains in Tennessee.

In Ohio, the highway runs up the western side through Dayton and Lima before crossing into Michigan north of Toledo.

Marie, downriver from Lake Superior, 1,786.5 miles (2,875.1 km) from its origins near the subtropical Atlantic Ocean.

After an intersection with the Homestead Extension of Florida's Turnpike and an interchange with I-595 and the Sawgrass Expressway (SR 869), the Interstate leaves the Miami metropolitan area and turns westward to travel through the Everglades along the tolled Alligator Alley, which brings the highway to the Gulf Coast and Naples, where it again heads north.

The freeway proceeds to enter suburban portions of Pasco, Hernando, and Sumter counties on its way to Ocala and Gainesville.

I-75 enters Georgia near Lake Park, and it continues northward through the towns of Valdosta, Tifton, and Cordele until it reaches the Macon area, where it intersects with I-16 eastbound toward I-75's route.

I-75 then runs concurrently with I-85 due north over the Downtown Connector through the central business district of Atlanta, where it intersects with I-20.

After the two Interstates split, I-75 diverts from I-85 and heads toward the northwest suburbs of Atlanta, with the major cities being Marietta and Kennesaw that it bypasses.

After the interchange with I-575, the highway leaves the Atlanta metro area and traverses the Blue Ridge Mountains in the north Georgia region as it heads toward Chattanooga.

When the two meet I-275, I-75 encounters some of its highest points of elevation through the Cumberland Mountains, cutting through the uppermost peaks and ridges.

I-75 continues northbound through the hilly terrain of the Cumberland Plateau region of Kentucky, passing through London and Richmond and eventually reaching Lexington, where it briefly runs concurrently with I-64 before splitting off in the direction of Georgetown.

After passing through Covington, the I-71/I-75 highway traverses the Ohio River via the lower level of the Brent Spence Bridge and continues into Downtown Cincinnati.

At Mackinaw City, I-75 makes an interchange with US 31 and US 23 before crossing the Mackinac Bridge to reach the Upper Peninsula of Michigan.

I-75 is the only Interstate located in the Upper Peninsula of Michigan and it continues until it crosses the Canadian border via the Sault Ste.

However, beginning in the 1960s, there was a huge growth in the population of Southwest Florida (Sarasota, Fort Myers, Naples, Cape Coral, etc.

[6] This included subsuming a toll highway from Naples to the Fort Lauderdale area, the Alligator Alley, and furthermore to connect this expressway with I-95 in North Miami—though due to some local opposition, I-75 presently ends a few miles short of I-95.