The Interstate 8 Athletic Conference is an athletic conference for high schools in Michigan formed in 2014 with eight schools in south central Michigan.

The conference currently consists of seven Class A and B schools from Barry, Branch, Calhoun, and Jackson counties.

The conference was founded in 2014 with the following charter members: Charlotte, Coldwater, Harper Creek, Jackson Lumen Christi, Jackson Northwest, Marshall, Parma Western, and Pennfield.

Hastings from the Ottawa-Kent Conference was selected to replace Charlotte starting in the 2016-17 school year.

[2] With Lumen Christi's departure, the remaining seven schools at some point or another participated in the old Twin Valley Conference that existed from 1931 to 2001.