The eight–team, Class C level Interstate Association consisted of franchises based in Indiana, Ohio and Michigan.
[2] The league was formed with teams representing Anderson, Indiana, Bay City, Michigan, Flint, Michigan (Flint Vehicles), Fort Wayne, Indiana (Fort Wayne Railroaders), Lima, Ohio (Lima Lees), Marion, Indiana (Marion Moguls), Muncie, Indiana (Muncie Fruit Jars) and Saginaw, Michigan teams beginning play on April 26, 1906.
[1][4] The Fort Wayne Railroaders were in first place when the Interstate Association folded on July 8, 1906.
[1] Fort Wayne finished with a record of 37–22, playing under managers Louie Heilbroner and Jack Hardy.
[1][5] Fort Wayne was followed by the Marion (36–24), Anderson (30–31) and Lima (26–36) teams in the final league standings.