[7][8] Hart and Jones centered the score's style on the period in which the show's protagonists live, intending to reflect African-American contributions to the New Orleans music scene.

[2] They discussed early 20th-century American classical musicians, including Florence Price, Aaron Copland, William Grant Still, Louis Armstrong, and Duke Ellington, as well as Trent Reznor's and Atticus Ross's score for the 2020 film Mank.

[4][9] Most of the music was performed in Vienna by the 49-piece orchestra of Synchron Stage;[2][9][13] as well as studios in London and Los Angeles,[13] with Hart remotely attended recording session because composing for the rest of the season was concurrent.

[9] For Louis de Pointe du Lac's theme, Hart focused on his moral struggle and melancholy temperament, mixing strings and wind instruments with piano melodies connecting him to his siblings.

[9] Due to the character's origins in the Old World, Hart wrote Lestat's theme in a traditional classical manner and accompanied it with brass instruments to underline his violence.

[4] "Permanent Exile" is a horror composition that is influenced by Wojciech Kilar's work in Bram Stoker's Dracula (1992), with a lot of extended technique, notably on the brass.

[4] Hart considered "In Throes of Increasing Wonder" as Louis's and Lestat's "love theme"; he was inspired by the chemistry between Jacob Anderson and Sam Reid during their first-kiss scene.

[2] "Are We the Sum of Our Worst Moments" is a "playful" piano-and-celesta piece that is supported by light strings and woodwind,[15] while "Come to Me" is written for Louis from Lestat's point of view and includes a vocal performance from Sam Reid.

[14] Tony Sokol of Den of Geek wrote the score is "exciting enough to move transitioning street thug Louis to perform a soft-shoe duet, and classically-trained musician Lestat to put a boogie-woogie rhythm to a Bach figured bass".

[24] The television series Interview with the Vampire also includes "Home Is Where You're Happy", which was written by American criminal and musician Charles Manson, and appears the end of the episode "A Vile Hunger for Your Hammering Heart".