The story takes place in an age where demi-humans, more casually known as "demis", have slowly started to become accepted into human society.

Tetsuo Takahashi is a biology teacher who ends up teaching three such demis, hoping to understand more about them while also managing to catch their attention.

[14][15] A spin-off manga written by Kae Hoshimoto, illustrated by Hajime Honda, with supervision by Petos, titled Occult-chan wa Katarenai, launched in Young Magazine the 3rd on 5 January 2019.

The series' scripts is written by Takao Yoshioka, character designs are done by Tetsuya Kawakami, and music is composed by Masaru Yokoyama.

[40] Crunchyroll simulcast the series as it aired while Funimation began releasing an English dub on 25 January 2017.

[49] He gave praise to the loveable main cast (singling out both Tetsuo and Hikari as highlights), the story's attention to detail in its worldbuilding of the demis and adding a bit of philosophy when interacting with them, concluding that "Overall, Interviews with Monster Girls delivers an entertaining and occasionally thoughtful package that avoids the seedier pitfalls common to the monster girl genre.