The family is named after the type genus Intrasporangium.

The type species of Intrasporangium (I. calvum) was originally thought to form endospores; however, the mycelium of this strain may bear intercalary vesicles that were originally identified as spores.

[3] No members of Intrasporangiaceae are known to form spores.

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature[2] and the phylogeny is based on whole-genome sequences.

[4][a] Intrasporangium Janibacter Tetrasphaera Pedococcus Phycicoccus Knoellia Dermacoccaceae