It spans 90,650 km2 (35,000 sq mi) of land,[3] mostly above the tree line, and includes several subregions: the Beaufort Sea, the Mackenzie River delta, the northern portion of Yukon ("Yukon North Slope"), and the northwest portion of the Northwest Territories.

Most of the ISR is represented by Nunakput, the territorial electoral district, meaning "our land" in Inuvialuktun.

[1] The Inuvialuit Settlement Region Database contains descriptions of thousands of publications and research projects about the ISR.

It is maintained by the Joint Secretariat—Inuvialuit Renewable Resource Committees[10] and the Arctic Science and Technology Information System.

Hunting, fishing and trapping are the major economic activities of Paulatuk, in Amundsen Gulf's Darnley Bay, and Sachs Harbour, the only permanent settlement on Banks Island.

Tuktoyaktuk, formerly known as "Port Brabant", is set on Kugmallit Bay, near the Mackenzie River Delta.

Herschel Island, which is uninhabited, is part of the ISR although in Yukon and was traditionally used by the Inuvialuit.

[17] Wildlife includes Arctic char, Arctic fox, beluga whale, bearded seal, bowhead whale, caribou, moose, muskox, polar bear, ringed seal, and whitefish.