[2] Align Technology founder Zia Chishti conceived of the basic design of Invisalign while an adult orthodontics patient.

[6] Orthodontists were resistant to adopting Invisalign at first, in particular because the founders had no orthodontic credentials or expertise, but the product became popular among consumers.

[5][10] In the early 2000s, Align Technology was spending nearly all of its revenues on marketing and advertising, and losing about $18 million per year.

Prescott re-focused the company on North America and cut the marketing budget to about one-third its original size.

[15] In February 2014, Align Technology released a G5 product designed With Kamalakannan Ganesan to treat deep bites.

[16] Support, software engineering, pre-production and administrative functions are done from Align Technology's headquarters in California.

The manufacturing of Invisalign aligners is performed in Mexico,[5] and treatment plans are created in Costa Rica.

Align Technology also operates separate subsidiaries in Hong Kong and Australia that sell Invisalign in their respective markets.

[25] In 2017 the company was faced with the challenge of the expiration of its patents on its Invisalign system starting in October 2017 and the beginning of generic competition.

[25] In March 2020, Align Technology announced that it has signed a definitive agreement to acquire exocad Global Holdings for approximately $418.7 million.