As she works on the experiment at home, while Molly hosts a dinner for her lacrosse team, a moth flies by and distracts Cleo, causing her to accidentally spill unknown chemicals into her solution.

The steam produced ends up turning the moth invisible, leading Cleo to chase it around the house, full of guests, before it gets away.

Things get complicated when George finds out Molly's invisibility, and her boyfriend Coug questions why she is constantly avoiding him.

The solution turns out to be too complex for either Cleo or George to understand, and they need Carter, a governor's scholar, to analyze the results.

With time running short, Cleo, George, Carter and Coug work together to develop an antidote for Molly, narrowly making the midnight deadline.

They nearly get in trouble when Mr. Perkins, in charge of the party, finds them in the barn, but Molly informs him about Cleo's experiment before drinking the antidote, risking the deadline.

Astonished by the results of Cleo's project, Mr. Perkins asks her to present her findings at a seminar of the New Orleans Association of Applied Scientists.

The film was officially announced on January 9, 2015, along with the casting of Rowan Blanchard and Paris Berelc as Cleo and Molly.

On February 27, Karan Brar, Rachel Crow, and Austin Fryberger were cast as George, Nikki, and The Coug.

[5] In Canada, due to a technical error at the end of the movie, the last ten minutes were replaced with the Teen Beach 2 music video, "That's How We Do".