A sequel to the 2018 Disney Channel Original Movie Zombies, the film stars Milo Manheim and Meg Donnelly, and features Trevor Tordjman, Kylee Russell, and Carla Jeffery reprising their roles from the first movie, with Chandler Kinney, Pearce Joza, and Baby Ariel joining the cast.

Soon after, though, Bucky announces his candidacy for class president which means that the cheer captaincy will go to someone else; Addison hopes to succeed A bus carrying the cheerleaders enters the nearby forbidden forest, Addison and the cheerleaders spot werewolves, which upon report to the local government, causes the mayor to reinstate anti-monster laws.

Werewolf prophecy states that a girl with white hair known as the Great Alpha will lead them to this moonstone, so the werewolves enroll at Seabrook to contact Addison.

Zed attempts to gain their vote for him by offering them advice on how to assimilate into Seabrook, which the werewolves ignore in favor of embracing their werewolf traits.

Noticing Addison's white hair, Wyatt, a high-ranking werewolf, invites her to their den, where they tell her the prophecy and give her a fully charged moonstone necklace, which they have saved for the Great Alpha.

Zed and Addison make up, however, the ground starts shaking and splits open with a blue glow from the hole.

[1] Pearce Joza, Chandler Kinney, and Ariel Martin joined the cast with Kylee Russell, Trevor Tordjman, Carla Jeffery, James Godfrey, and Kingston Foster reprising their roles from the first film.

[9] During its premiere on February 14, 2020, in the 8:00 PM time slot, Zombies 2 attracted a total of 2.46 million viewers, with a 0.52 rating for people aged 18–49.

On May 20, 2022, RuPaul was announced to have joined the cast as the voice of "The Mothership", described in the official synopsis as "a comedically passive-aggressive UFO".