[1] Three miles into Buena Vista County, Iowa 110 turns to the east at Buena Vista County Road C65 (CR C65).

For 2+1⁄2 miles (4.0 km), the route heads east, turning to the north again near the southwestern shore of Storm Lake.

It continues north past the western shore for 2 miles (3.2 km) and negotiates an S-curve around the northwestern shore and into the city of Storm Lake.

[2] Iowa Highway 110 was designated in 1934 on an old segment of Primary Road No.

[4] By 1970, Iowa 110 was rerouted away from the downtown area to its current western end.