It begins at U.S. Highway 18 (US 18) in Inwood and ends at Iowa 9 southeast of Larchwood.

Iowa Highway 182 begins at an intersection with US 18 and County Road A42 (CR A42).

Iowa 182 travels north through Inwood for one mile (1.6 km) and continues due north through the farmland of Lyon County for eight miles (13 km) to an intersection with Iowa Highway 9.

[3] Iowa 26 was extended north from Rock Valley back to US 18 in 1929.

[7] In this case, the former Iowa 182 in Allamakee County crossed into Minnesota and became Trunk Highway 26.