[1] He was nephew to his father's brother, Cardinal Marcello Lante della Rovere.
He made a number of significant improvements to the Villa and its gardens, and commissioned Pietro da Cortona to paint the Allegory of War and Peace.
Lante's plan had been to alter the villa with more baroque art and architecture to move the estate away from the defensive military style with which it had first been built.
Some of his initial plans were accomplished, but the buildings remain a mix of architectural types.
On 11 February 1688, he married Maria Cristina d'Altemps, daughter of Pietro d'Altemps (Duke of Gallese and Marquis of Soriano) and Angelica de' Medici [it] (granddaughter of Giulio de' Medici).