Irène du Buisson de Longpré (c. 1720–1767), was a French noblewoman, mistress to Louis XV of France.
She was apparently at one point employed in the household of the king's daughter, Princess Adélaïde.
She is described by Jean-François Marmontel in his memoirs as a woman known for her affairs.
In around 1750, she attracted the attention of Louis XV, with whom she had an affair at about the same time as the king's affair to Marie Geneviève Radix de Sainte-Foy.
Not long after this, Louis XV had Marie-Louise O'Murphy installed at the Parc-aux-Cerfs.