Following the revolution, Iran ended its alliance with Israel and started supporting the Palestinians, symbolized by turning over the Israeli embassy in Tehran to the Palestine Liberation Organization.

The renewed support became evident when Israeli commandos captured the Karine A in 2002, a ship carrying 50 tons of advanced weaponry from Iran to Gaza.

[9] In September 2010, former Iranian President Mahmoud Ahmadinejad said that the peace talks in Washington would not achieve their goals, because Hamas is the true representative of the Palestinian people, among other reasons.

Fatah spokesman Osama Al-Qawasmi said that Iran is striving to divide Palestine, to spark civil wars and sectarian and ethnic strife in numerous Arab regions, and therefore it cannot benefit the Palestinian people.

[10] On 3 April 2024, the ruling Fatah party released a statement opposing Iranian involvement in Palestinian affairs, asserting that "this external interference, particularly by Iran, has no other objective than to sow chaos in the Palestinian internal arena, which will only benefit the Israeli occupation and the enemies of our people".