Irene Doukaina Laskarina (Bulgarian: Ирина Ласкарина Асенина, Greek: Ειρήνη Δούκαινα Λασκαρίνα) was empress consort (tsaritsa) of Bulgaria (1258–1268).

Her maternal grandparents were Tsar Ivan Asen II and Anna Maria of Hungary.

In 1257, Irene married Bulgarian nobleman Constantine Tikh as his second wife.

In the next year Constantine was elected Tsar of Bulgaria by a boyar council in Tarnovo and Irene become his consort.

In 1261 Irene's young brother, Emperor John IV Laskaris, was deposed and blinded by Nicaean regent Michael VIII Palaiologos, who had just regained Constantinople from the Latin Empire, re-establishing the Byzantine Empire.