Irene Lake is a freshwater body of the southeastern part of the Eeyou Istchee James Bay (municipality), in Jamésie, in the administrative region of Nord-du-Québec, in the province of Quebec, in Canada.

Forestry is the main economic activity of the sector.

The hydrographic slope of Lake Irene is accessible through the R1032 forest road (North-South direction) which passes on the west side of the lakes Gabriel and Irene; in addition, this road crosses the Irène River (Opawica River) south of Irène Lake to merge south along route 212 which passes on the south side of the Irène River, connecting Obedjiwan to La Tuque.

The surface of Irene Lake is usually frozen from early November to mid-May, however, safe ice movement is generally from mid-November to mid-April.

The mouth of this lake Irene is located at the bottom of a bay north of the lake, to: The main hydrographic slopes near Lake Irene are: The toponym "lac Irene" was made official on December 5, 1968 by the Commission de toponymie du Québec, when it was created.