The Irene River is a tributary of the Opawica River, flowing into the Municipality of Eeyou Istchee James Bay (municipality), in Jamésie, in the administrative region of Nord-du-Québec, in Quebec, in Canada.

This river crosses successively the cantons of Fancamp and Rasles.

The surface of the Irene River is usually frozen from early November to mid-May, however, safe ice circulation is generally from mid-November to mid-April.

The Irene River originates at the mouth of Three Islands Lake (length: 1.8 kilometres (1.1 mi); elevation: 378 metres (1,240 ft)) in the township of Fancamp, in Eeyou Istchee James Bay (municipality).

The toponym "Irène River" was made official on December 5, 1968, at the Commission de toponymie du Québec, when it was created.