She made several recordings in the 1910s, and toured the United States and Canada on the Chautauqua circuit in the 1920s.

[2][3] She trained as a violinist with Hugh (Harry) Dimond at the Metropolitan Conservatory of Music in Chicago.

[6] In the 1919–1920 season, she toured with Bohumir Kryl's Orchestral Sextette, as the group's leader.

[7] She was active on the Chautauqua circuit in the 1920s, billed as the Irene Stolofsky Company, working with various vocalists and pianists, including Grace Johnson Konold, George Imbrie, Magdalene Massman, and Herbert Macfarren.

[8][9][10] "Miss Stolofsky is quite a dazzling virtuoso," wrote one California critic in 1923, "She is very certain in her technique, and never flinches at such an exhibition of fireworks as is contained in Hubay's Scenes de la Szarda.