Saint Irene of Rome (died 288 AD) was a Christian woman in the Roman Empire during the reign of Diocletian.

According to Christian legend, she attended to Saint Sebastian after he was wounded by Mauretanian archers.

Irene was the wife of Saint Castulus who, according to tradition, was in the service of the Roman emperor.

[1] After the death of her husband, Irene continued to be active in the Christian community in Rome.

According to hagiography, when Saint Sebastian was shot with arrows for practicing Christianity, Irene tended his wounds.