Irina Sabine Alice Karamanos Adrian (born 29 October 1989) is a Chilean social science professional.

Karamanos is an influential figure in her political party, Social Convergence, where she leads the Feminist Front.

Initially, both she and Boric opposed the existence of the First Lady role, with Karamanos stating that it needed to be rethought to reflect the changing times and power dynamics.

She expressed her intention to focus on issues related to transgender rights and child migration.

[5] The decision to assume the role and preserve its existence was met with both support and pushback from various feminist groups in Chile.