On May 6, 1891, Eugène Ysaÿe invited her to perform with him at St. James's Hall in London in works by Felix Mendelssohn, Piotr Ilitch Tchaikovsky and Henryk Wieniawski.

During the period 1894 to 1911, she collaborated with many artists: Marguerite Swale, Gustav Ernest, Alfred Reisenauer, Paul Ludwig, George Henschel, Henry Bird, Eleanor King, Louis Hillier, Waldemar Lütschg and Erna Klein.

On March 12, 1897, Louis Hillier accompanied her on the piano at St. James Hall in London, notably in his piece Serpentine which he dedicated to her.

In 1939, the Saenger-Sèthe couple fled Europe for the United States, taking a boat in Lisbon to reach New York on March 26, 1941, where they joined their youngest daughter Magdalene.

Living with her eldest daughter Elisabeth in New York, she died at the age of 82, leaving among her personal belongings her child's half violin, which became part of the collections[5] of the Royal Library of Belgium in June 2022.