Irondale is a city in St. Francois County, Missouri, United States.

The racial makeup of the city was 97.5% White, 0.2% Native American, and 2.2% from two or more races.

20.6% of all households were made up of individuals, and 6.3% had someone living alone who was 65 years of age or older.

The racial makeup of the city was 97.71% White, 0.23% Native American, 0.46% Asian, and 1.60% from two or more races.

29.0% of all households were made up of individuals, and 11.2% had someone living alone who was 65 years of age or older.

Irondale was laid out in 1857 by John G. Scott, who built an iron furnace there.

It was opened in 1920, closed and was replaced by the S-F Scout Ranch in August 1965.