It was founded in 1924 as a part of the current West Irondequoit Central School District.

To match this expansion in school attendance, the kitchen, library, chemistry and biology labs, and offices were expanded.

The school has varsity through modified teams for the fall, winter, and spring under the nickname Irondequoit Eagles.

As of 2023, Irondequoit participates in football, soccer, volleyball, tennis (for females), cross country, and field hockey in the fall; basketball, Nordic skiing, snow-sports club, bowling, ice hockey, cheerleading, swimming and diving, and indoor track and field in the winter; and lacrosse, baseball, track and field, tennis (men's), and softball in the spring.

[5] The boys' varsity lacrosse team has had a losing record just twice (2017, 2020) in over 25 years of play.