A So So Def remix of the piece features Lil' Bow Wow and Jermaine Dupri, and incorporates samples of Kool & the Gang's "Jungle Boogie" (1973).

The accompanying music video, directed by Simon Brand, has a James Bond theme and features scenes of Simpson dressed as a spy.

A music video for the So So Def remix was also filmed, featuring appearances by Dupri and Lil' Bow Wow inter-cut with scenes of Simpson.

Despite not charting within the top twenty in Australia, it was certified gold by the Australian Recording Industry Association (ARIA) for shipments of more than 35,000 copies within the country.

[7] In an interview, Birgisson commented on the collaboration with Sheyne saying that: "Pam came up with the title 'Irresistible', and as she started talking about the whole concept we immediately became inspired and began working on the music.

"[6] Vocals were recorded and engineered by Robert Williams using a Sony C-800G Studio Tube condenser microphone[8] while post-recording editing, via the Pro Tools software, was done by Peter Wade Keusch.

[3] The Dallas Morning News' Teresa Gubbins observed that the track possesses a rat-a-tat-tat beat, similar to "There You Go" (2000) by singer Pink.

[19] This can be inferred from the lines "I know that I'm supposed to make him wait / Let him think I like the chase / But I can't stop fanning the fire / I know I meant to say no… / But he's irresistible,"[19] Bob Waliszewski of Plugged In (publication) pointed out that the verses "I can't stop fanning the fire [...] Now inescapable" refer to an "imminent sexual compromise".

[23] According to Slant Magazine, the Hex Hector remix of the song uses full-throated vocals by Simpson, and includes disco-influenced string arrangement, which is comparable to the musical style of Giorgio Moroder, and utilizes beats from a Roland TR-808.

[23][24] Ron Thal, the lead guitarist of the hard rock band Guns N' Roses, plays guitar on the remix tracks.

[26] Brendan Frederick of Complex wrote that while the remix could not do anything to complement the original track's chart performance, it helped achieve a "gimmicky redemption".

He also noted that although the samples were used in the song "Satisfy You" by Puff Daddy about one and a half year ago, the remix of "Irresistible" sounded "kinda [sic] sweet".

[13] Similarly, Chuck Taylor of Billboard reviewed "Irresistible" favorably, calling it "a sexy, uptempo romp about new found love that proves Simpson's pop intuition.

[3] Teresa Gubbins of The Dallas Morning News had mixed feelings towards the song in her review, writing that its sound might help Simpson get attention on urban radios, but did nothing to demonstrate her voice.

"[43] However, Siobhan Grogan of NME magazine stated "to the delight of lonely men everywhere, she tells us she's 'weak with desire' and knows 'I'm meant to say no'—and the mind boggles at how she'd have turned out if she'd spent her teens glugging cider on a street corner.

"[46] The Northern Echo's Hayley Gyllenspetz dismissed the song, elaborating that it sounded similar to the works of Britney Spears and Christina Aguilera.

"[47] An editor of The Malay Mail echoed Gyllenspetz's comment, writing that the track sounded like a typical Aguilera pop-Latino piece.

[12] Simon P. Ward from Dotmusic compared the song to the work of Britney , Christina, and Jennifer Lopez and felt that "Irresistible' will doubtless further Simpson's cause as the next poster girl for all discerning adolescents.

[51] "Irresistible" experienced moderate commercial success worldwide, reaching the top forty of the charts in eleven countries.

In the United States, the song initially debuted at number five on the Billboard Bubbling Under Hot 100 Singles chart, on the issue dated May 5, 2001.

[58] In Canada, "Irresistible" debuted at number sixteen on the Canadian Singles Chart, on the issue of August 4, 2001, and stayed on the Top 100 for fifteen weeks .

[70] Fraser Middleton of The Evening Times wrote that Simpson captured a "girl next door" image with her previous album and the music videos for its accompanying singles.

[73] The music video was directed by Colombian film director Simon Brand,[74] in Los Angeles,[75] and was choreographed by Dan Karaty.

[3] Similarly, Melissa Ruggeri of The Richmond Times-Dispatch also gave a positive review, writing that the term "Irresistible" fitted the video.

[85] Therefore, Simpson made the choreography more risqué by adding backup dancers and performing dance moves in revealing outfits.

[87] Her performance was commended by The Richmond Times-Dispatch, who wrote that her voice "soared,"[88] but criticized by The Buffalo News' Andrea Kibler and St. Louis Post-Dispatch's Kevin C. Johnson, both of whom opined that Simpson was lip-syncing the whole song.

[100] In late 2001, Simpson sang the song as part of MTV's Spring Break program, held in Cancún, Mexico.

[102][103] In 2002, Simpson sang "Irresistible" at Rockin' for the USA, a music special honoring the United States Armed Forces.

[105] On the Houston stop of the North American leg of the tour, Simpson performed "Irresistible" at the end of the show, before singing "With You", a song from In This Skin, as the encore.

[107] Her performance was approved by Dustin J. Seibert of The Cincinnati Enquirer, who wrote that "Simpson's reliance on her high-octane voice and bubbly personality set her apart from some of her pop counterparts.