The Irvine Transportation Center effectively became an inaugural station of the new line, and service was increased from the original once-a-day Commuter schedule.

[3] Irvine Transportation Center is served by 20 Amtrak Pacific Surfliner trains (ten in each direction) evenly spaced throughout the day.

[13] Irvine Transportation Center is served by 26 Metrolink Orange County Line trains (13 in each direction) each weekday, evenly spaced throughout the day.

Weekend service consists of 4 trains (2 in each direction) on both Saturday and Sunday, heading towards Orange County in the morning and towards the Inland Empire in the evening.

[14] FlyAway (bus) coach service to Los Angeles International Airport was formerly provided from the station, but was discontinued due to low ridership.