She is also the younger sister of Onno Hoes, who was the mayor of Maastricht as of 1 November 2010 till 30 June 2015.

Hoes graduated from the Toneelacademie Maastricht (Academy of Dramatic Arts).

Recently, she has become the voice of Heather from Total Drama in the Dutch version of the series.

Isa Hoes was married to the actor Antonie Kamerling.

[3] The film Toen ik je zag is based on their relationship and the events and circumstances leading up to Kamerling's suicide.