Isa Khan Safavi (Persian: عیسی خان صفوی), also known as Isa Khan Shaykhavand (آوند عیسی خان شیخ) was a Safavid prince, who occupied high offices under king (shah) Abbas I (r. 1588–1629).
Isa Khan was the grandson of the Safavid vizier Masum Beg Safavi, and was married to one of Abbas' daughters.
In 1612, he was appointed by Abbas I as the head of the royal bodyguard (qurchi-bashi).
[1] In 1625, Isa Khan was appointed as the commander of the Safavid army of Georgia and fought a group of Georgian rebels on June 30.
[2] In 1629, Abbas I died and was succeeded by his grandson Safi, who in 1631 executed Isa Khan including his three sons.