He was the pupil and successor of Isaac Campanton, and was called "the last gaon of Castile."
Later, he lived in Buitrago and Guadalajara and served as head of yeshiva in these cities.
[1] After Ferdinand and Isabella issued the decree of expulsion in 1492, he with thirty others of the most respected Jews of the land went to Lisbon in order to negotiate with King John II of Portugal for the reception of his banished coreligionists.
He and his companions were allowed to settle under favorable conditions in Porto.
His disciple, the chronicler and mathematician Abraham Zacuto, delivered his funeral address.