Chamberlain made his professional debut in January 2015, defeating Moses Matovu in a four-round points victory.

[1] In September 2016, Chamberlain won the BBBofC Southern Area cruiserweight title with a points victory over Wadi Camacho.

He fought London rival Lawrence Okolie on 3 February 2018 at the O2 Arena in a Sky Sports card headlined "British Beef", losing a wide unanimous decision after having been knocked down twice.

[2] In preparation for the fight, Chamberlain visited Ukraine to spar with cruiserweights Oleksandr Usyk and Mateusz Masternak.

[3] Chamberlain has worked as a sparring partner for former WBC heavyweight champion Deontay Wilder.