Before her death a decade later, she bore three children, but only one survived to adulthood --Isaac Coles Jr.(1777-1814) -- who (briefly) inherited his father's lands in Halifax County and also served in the Virginia House of Delegates.

[6] In 1787, Coles owned 3,896 acres of land, as well as 32 enslaved adults, 34 children, 24 horses and 97 other livestock, as well as 4 phaeton wheels in Halifax County.

[8] Halifax County voters also elected Isaac Coles as one of their representatives to the Virginia Ratifying Convention, which assembled in June 1788.

However, his marriage in New York City proved a political liability, as perhaps did his shift toward the Federalist party of his brother-in-law, for he lost to Matthew Clay, who had repeatedly reminded voters that the widower failed to remarry a Virginia woman.

His son Walter Coles would also carry on the family's political and planter traditions, and served in the House of Representatives as had his father.

1780 at Enniscorthy, Albemarle County and brother of future Illinois governor Edward Coles) served as personal secretary to Presidents Thomas Jefferson and James Madison during their administrations.

Another nephew Isaac H. Coles served in the Virginia senate, representing Charlotte, Halifax and Prince Edward Counties.