His publishing career spanned nine years and dominated the Leiden University printing business.
Isaac began his career buying a print shop in Leyden in 1616 and by 1620 was appointed Printer to Leiden University.
In 1625 Isaac brought the printing business of Thomas van Erpe with oriental fonts from his widow for the very large sum of 8000 guilders.
Isaac left Leyden after selling the printing business and purchased a tavern in Rotterdam.
A man stands beside the tree which supports a banner bearing the Latin motto Non Solus (not alone).