Isaac Gere (1764 in Groton, New London County, Connecticut – May 12, 1849) was an American politician from New York.
He married Deborah Wright (1773–1849), and they had several children.
He was a member of the New York State Assembly (Saratoga Co.) in 1816 and 1824.
He was a member of the New York State Senate (4th D.) from 1830 to 1834, sitting in the 53rd, 54th, 55th and 56th New York State Legislatures.
He was buried at the Village Cemetery in Galway, NY.