Isaac Griffin (February 27, 1756 – October 12, 1827) was a veteran of the American Revolutionary War and member of the U.S. House of Representatives from Pennsylvania, serving two terms from 1813 to 1817.
He appointed justice of the peace in 1794 and was elected a member of the Pennsylvania House of Representatives in 1807 and served four terms.
Griffin was elected as a Democrat-Republican to the Thirteenth Congress to fill the vacancy caused by the death of John Smilie.
He died from the effects of a fall from a wagon, on his estate in Nicholson Township, Pennsylvania, on October 12, 1827.
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