[6][5] Coming out of high school, Guerendo decided to commit to play college football for the Wisconsin Badgers.
[20] In week ten of the 2023 season, Guerendo had a career performance rushing for 146 yards and three touchdowns in a win over Virginia Tech.
[21] In the 2023 Holiday Bowl, Guerendo rushed for a career high 161 yards and three touchdowns, on 23 carries, but the Cardinals lost to USC 42–28.
[29] After injuries to running backs Christian McCaffrey and Jordan Mason,[30] he had some playing time, making his debut in week 2 against the Minnesota Vikings in a 23–17 loss.
Mario is an emigrant from the Central African Republic, and Jen competed in track & field in high school.