Isaac Hodgson (16 December 1826 – August, 1909) was an Irish architect who worked primarily in Indiana and Minnesota.

He was born in Belfast, Ireland in 1826 and studied at the Royal Academy.

He went to work for architect Sir Charles Lanyon at the age of 16.

He designed six Indiana courthouses, including the ones in Bartholomew, Jennings, Morgan and Henry counties.

Hodgson was one of eight charter members of the Indiana Chapter of the American Institute of Architects and relocated to Minnesota about 1882 where he designed a number of notable buildings in partnership with his oldest son, including the Industrial Exposition Building in 1886.