Isaac Hughes (1798 – 23 June 1870) was a British Calvinist missionary and preacher.
He was born to Welsh parents Edward and Mary Hughes in Manchester.
[1] After some time in Sheffield and Rotherham, he married Elizabeth Jones from Llangollen on 18 August 1823 and departed Britain a month later on 24 September on a ship from Gravesend, arriving in Cape Town, South Africa on 30 December.
[1] In 1845 he worked along the Vaal River and opened a new station in Backhouse, which later developed into the town Douglas.
After his wife died he remarried a missionary's daughter, Anne Magdalena Vogelgezang, in 1850.