Isaac L. Anderson (1780–1857) was a Presbyterian minister and the founder in 1819 of Southern and Western Theological Seminary in Maryville, Tennessee.

A native of Rockbridge County, Virginia, Dr. Anderson was educated in a traditional log school house after he was taught to read and spell by his grandmother.

Later he attended Liberty Hall Academy, present-day Washington and Lee University, in Lexington, Virginia.

Anderson continued as pastor of Washington Church until 1812 when he moved to Maryville, TN to become pastor at New Providence Presbyterian Church.

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