Isaac Lawrence Milliken (August 29, 1813 – December 2, 1889) served as mayor of Chicago, Illinois from 1854 to 1855.

Born in Saco, Massachusetts (now in Maine), Milliken moved to Chicago in 1837 and set up a blacksmith shop on Randolph Street.

[4][5] Here, Milliken taught himself law and was twice elected alderman and appointed an assistant county judge.

[5] In the election of 1854, Milliken defeated Amos Gaylord Throop, who ran on the Temperance Party ticket, with nearly 60% of the vote.

[8] He ran for re-election the following year against Levi Boone, of the American Party and lost with 47% of the vote.